For every symptom you elicit (whether it’s the presenting complaint or not), you must ask a series of further, symptom-specific questions – this is called exploring the symptom. After this, you must also ask relevant system review questions to determine the presence/absence of any significant associated features (see systems review).
For all symptoms also review the timeframe
Onset: sudden or gradual (if sudden, what were they doing at the time?)
Timing: intermittent or continuous (if intermittent, are there any triggers/associations?)
Clarify what they mean by tiredness
Constant or episodic?
Ask about sleep
How it affects the patient
Anaemia symptoms: breathlessness on exertion, dizziness/headache
Hypothyroidism symptoms: constipation, weight gain, cold intolerance, menorrhagia