Learn how to perform one too…
Performing an ABG is covered here!
Normal values |
pH | 7.35-7.45 |
pCO2 | 4.5-6.0 kPa |
pO2 | 11-13 kPa |
HCO3– | 22-26 mmol/l |
BE | -2 to +2 |
SaO2 | >95% |
Lactate | <2 |
Step 1 – OxygenationÂ
– Hypoxaemic? (i.e. Is the PaO2 <11kPa?)Â
– Is there impaired oxygenation?
– Oxygenation takes into account the percentage of oxygen the patient is on (the fraction of inspired oxygen or FiO2)
– PaO2Â should be approximately 10kPa less than the FiO2Â percentage
Respiratory failure:
– Type 1 = 1 gas abnormal (↓O2)
– Type 2 = 2 gases abnormal (↓O2 + ↑CO2)
Step 2 – pHÂ status
Determine pH status:
– Acidosis (pH↓)
– Alkalosis (pH↑)
Step 3 – Respiratory component
Determine respiratory component (PaCO2):
– Respiratory acidosis (pH↓, PaCO2↑)
– Respiratory alkalosis (pH↑, PaCO2↓)
If the PaCO2 doesn’t agree with the pH, ignore it until step 5
Step 4 – Metabolic component
Determine the metabolic component (HCO3- or BE):
– Metabolic acidosis (pH↓, HCO3–↓)
– Metabolic alkalosis (pH↑, HCO3–↑)
If the HCO3– doesn’t agree with the pH, ignore it until step 5
Step 5 – Combine
– Primary disturbance
– Compensation
See below
Step 5 (continued)
- Primary disturbance: you know this from the above steps
- NB. both the respiratory and metabolic component may have agreed with the pH ie. a ‘mixed respiratory and metabolic acidosis/alkalosis’
- Compensation: If either the respiratory/metabolic component was not consistent with the pH, there is compensation…
- Acidosis may be compensated byÂ
- Respiratory compensation: increasing respiratory rate to blow off CO2 (will result in ↓CO2)Â
- Metabolic compensation: increased bicarbonate production by kidney (will result in ↑HCO3–)
- Alkalosis may be compensated byÂ
- Respiratory compensation: decreasing respiratory rate to retain CO2 (will result in ↑CO2)Â
- Metabolic compensation: decreased bicarbonate production by kidney (will result in ↓HCO3–)
- Partial compensation = pH not quite back to normal yet; full compensation = pH normal (you cannot over-compensate)
- NB. You can’t fully compensate metabolic alkalosis (you can only hypoventilate a bit). Metabolic compensation by the kidneys takes 3 days, respiratory compensation is fast.
- ± Respiratory failure
- Type 1 = 1 gas abnormal (↓O2)
- Type 2 = 2 gasses abnormal (↓O2 + ↑CO2)
Causes of Acid-Base Mismatch
Causes of Respiratory Failure
Type 1 = 1 gas abnormal = ↓O2, normal CO2
Caused by impaired diffusion (e.g. pneumonia, ARDS, pulmonary fibrosis) or ventilation-perfusion (V/Q) mismatch, ie. either:
- Low V/Q: areas of lung are perfused with deoxygenated blood but not ventilated with oxygen (ie. airway obstruction)
- Causes: mucus plug in asthma/COPD, airway collapse in emphysema
- High V/Q: areas of lung are ventilated with oxygen but not perfused with deoxygenated blood (ie. block in blood flow)
The reason CO2 is normal is that the areas of the lung which are perfused and ventilated can blow off extra CO2 by increasing ventilation rate (making CO2 low in this area and high in the area with V/Q mismatch which makes it normal overall). Extra oxygen, however, cannot be absorbed (without giving a higher oxygen concentration) because the maximum amount of oxygen diffuses across the alveolar membrane in normal circumstances anyway.
Type 2 = 2 gasses abnormal = ↓O2, ↑CO2
Caused by alveolar hypoventilation. This means oxygen cannot get into alveoli and carbon dioxide cannot get out.
Causes: obstructive lung diseases (e.g. COPD), restrictive lung diseases, decreased respiratory drive, neuromuscular disease, thoracic wall disease
Lactic Acidosis
- Lactic acid = a product of anaerobic metabolism
- Types of lactic acidosis
- TYPE 1 (hypoxic) = produce too much lactic acid (e.g. DKA, starvation, cardiovascular/respiratory depression)
- TYPE 2 (non-hypoxic) = cannot break down lactic acid (e.g. secondary to metformin or poisoning)
Common ABG patterns
NB. Respiratory alkalosis ∆∆ = hyperventilation (↑O2), asthma exacerbation (normal O2), PE (↓O2)
Why don’t you try an example?
A 49 year old patient has been brought to the emergency department with breathlessness and a reduced GCS. Their chest sounds wheezy on auscultation. Please review the patient’s ABG :
pH 7.25 (7.35-7.45)
pCO2 7.7 (4.5-6)
pO2 7.6 (11-13)
HCO3- 14.7 (22-26)
BE -6 (-2 to +2)
Oops! This section is restricted to members.
What are the potential causes?
Oops! This section is restricted to members.
How would you manage this patient?
Oops! This section is restricted to members.
One more?
A 34 year old female is brought to the emergency department unresponsive. Her medical history is unknown. Her arterial blood gas is shown:
pH 7.18 (7.35-7.45)
pCO2 4.7 (4.5-6)
pO2 11.6 (11-13)
HCO3- 11.7 (22-26)
BE -9 (-2 to +2)
Oops! This section is restricted to members.
What would you like to check next to help work out the cause?
Oops! This section is restricted to members.
Which results would you like now?
Oops! This section is restricted to members.
What is the diagnosis and the immediate management?
Oops! This section is restricted to members.
Now try some OSCE stations
- Diabetic ketoacidosis
- COPD data interpretation
- Hyperkalaemia
- Find more stations here