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Visual hallucinations

Differential Diagnosis Schema 🧠

Neurological Causes

  • Charles Bonnet Syndrome: Visual hallucinations in cognitively intact individuals, usually with significant visual impairment
  • Lewy Body Dementia: Recurrent, well-formed visual hallucinations, often associated with cognitive fluctuations and parkinsonism
  • Parkinson’s Disease: Visual hallucinations, particularly in advanced stages, often linked to dopaminergic treatment
  • Migraine with Aura: Transient visual disturbances, such as scintillating scotomas, occurring before or during a headache
  • Epilepsy (Occipital Lobe Seizures): Simple visual hallucinations (e.g., flashing lights) during or following a seizure

Psychiatric Causes

  • Schizophrenia: Visual hallucinations, often with auditory hallucinations and delusions
  • Delirium: Acute onset visual hallucinations with fluctuating consciousness, often in the context of an underlying medical condition
  • Major Depressive Disorder with Psychotic Features: Severe depression with mood-congruent or mood-incongruent visual hallucinations
  • Bipolar Disorder (Manic Phase): Visual hallucinations during manic episodes, often accompanied by grandiosity and hyperactivity

Substance-Related Causes

  • Alcohol Withdrawal (Delirium Tremens): Visual hallucinations, often alongside tremors, agitation, and autonomic instability
  • Substance Intoxication (e.g., LSD, cannabis): Visual distortions or hallucinations depending on the substance used
  • Substance Withdrawal (e.g., benzodiazepines): Visual hallucinations may occur during withdrawal, particularly from sedatives
  • Medications (e.g., anticholinergics, dopaminergic drugs): Drug-induced visual hallucinations, dose-related, reversible with cessation

Key Points in History πŸ₯Ό

Presenting Symptoms

Assess the specific symptoms presented by the patient:

  • Description of Hallucinations: Nature, frequency, duration, and content of the hallucinations (e.g., simple vs. complex, animals, people)
  • Onset and Triggers: Sudden vs. gradual onset, any precipitating factors (e.g., stress, substance use, visual impairment)
  • Associated Symptoms: Presence of cognitive changes, motor symptoms, or mood disturbances
  • Impact on Function: Effect on daily activities, insight into hallucinations, any distress or safety concerns

Background

Gather a detailed background including:

  • Past Medical History: Previous psychiatric diagnoses, history of neurological disorders (e.g., Parkinson’s, epilepsy), or known visual impairment
  • Drug History: Review current medications for potential side effects, recent changes in drug regimen, or use of recreational substances
  • Family History: Any family history of psychiatric or neurological conditions
  • Social History: Alcohol and drug use, recent significant life events, social support, and living conditions

Possible Investigations 🌑️

Physical and Neurological Examination

  • General Physical Examination: Assess for signs of systemic illness (e.g., infection, organ failure) that could contribute to delirium
  • Neurological Examination: Check for focal neurological deficits, signs of Parkinsonism, or features suggestive of epilepsy
  • Mental Status Examination: Assess orientation, attention, memory, and thought processes for signs of delirium, dementia, or psychosis
  • Ophthalmological Examination: If visual impairment or Charles Bonnet syndrome is suspected, assess visual acuity and fields

Imaging and Diagnostic Tests

  • Brain Imaging (e.g., MRI, CT): To identify structural abnormalities (e.g., stroke, tumor) or neurodegenerative changes
  • Electroencephalogram (EEG): To assess for epileptiform activity, especially if seizures are suspected
  • Blood Tests: To rule out metabolic causes (e.g., glucose, electrolytes, liver and kidney function tests), and screen for infection or substance levels
  • Toxicology Screen: Particularly if substance misuse or overdose is suspected
  • Cognitive Testing: Formal assessment for dementia, particularly if Lewy Body Dementia is suspected

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