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Introduction
Motor Neurone Disease (MND) is a progressive neurodegenerative disorder that affects motor neurones in the brain and spinal cord, leading to muscle weakness and wasting. The most common form of MND is Amyotrophic Lateral Sclerosis (ALS).
Epidemiology
Pathophysiology
MND primarily affects the upper motor neurones in the brain and lower motor neurones in the spinal cord. The exact cause is unknown, but several mechanisms are proposed:
Clinical Features
MND presents with a combination of upper and lower motor neurone signs:
Diagnosis
Diagnosis of MND is primarily clinical, supported by investigations to exclude other conditions:
Management
There is no cure for MND, but management focuses on symptom control and supportive care:
Prognosis
The prognosis of MND is generally poor, with most patients surviving 2-5 years after diagnosis. However, there is significant variability, with some patients living longer. Factors influencing prognosis include age of onset, disease progression rate, and respiratory function at diagnosis.