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A condition characterised by reduced blood supply to the heart muscle, usually due to coronary artery disease (CAD).
Epidemiology
IHD is a leading cause of death worldwide, however, due to population-wide primary prevention initiatives, the number of deaths globally have been declining.
Pathophysiology
Narrowing or blockage of coronary arteriesΒ reduces oxygen supplyΒ to the myocardium.
Prolonged ischaemia can lead to myocardial infarction.
Aetiology/Risk Factors
Most commonly caused by atherosclerosis of the coronary arteries.
Risk factors:
Hypertension
Hyperlipidaemia
Smoking
Diabetes
Family history
Age
Gender
Obesity
Clinical Features π‘οΈ
Symptoms
Angina pectoris:Chest pain or discomfort, often radiating to the left arm, neck, or jaw. Symptoms are triggered by exertion or stress.
Myocardial infarction: Severe, prolongedchest pain; associated with nausea, sweating, and shortness of breath.
Silent ischaemia:Asymptomatic episodes of myocardial ischaemia.
Patients with diabetes mellitus are more susceptible to silent episodes.
Investigations π§ͺ
Initial Tests
Electrocardiogram (ECG): Detects ST-segment changes, T-wave inversions, and Q waves suggestive of ischaemia or infarction.
Blood tests:Cardiac enzymes (troponin, CK-MB) rise after myocardial infarction.
Diagnostic Tests
Coronary angiography:Gold standard for visualising coronary artery blockages.
Stress testing and myocardial perfusion imaging to evaluate the functional significance of coronary lesions.
Management π₯Ό
Management
Pharmacological:Antiplatelets (aspirin, clopidogrel), statins, beta-blockers, ACE inhibitors, and nitrates.
Revascularisation:Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for significant obstruction or uncontrolled symptoms.
Lifestyle modifications:Smoking cessation, diet, exercise, and weight management.
Prognosis
Early detection and treatmentΒ improve outcomes.
Complications
Heart failure
Arrhythmias
Sudden cardiac death
Recurrent myocardial infarction
Key Points
IHD is characterised by an imbalance between blood oxygen supplyΒ and metabolic demand of the myocardium.
Coronary angiography is the gold standard diagnostic test.
Management includes both pharmacological and revascularisation interventions in addition to lifestyle modifications.
References
Office for National Statistics (2021). Ischaemic heart diseases deaths including comorbidities, England and Wales – Office for National Statistics. [online] www.ons.gov.uk. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/ischaemicheartdiseasesdeathsincludingcomorbiditiesenglandandwales/2019registrations.
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Which of the following is not a recognized risk factor for ischaemic heart disease?
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50% of users got this question correct
Answer Explanation:
The correct answer is raised high-density lipoprotein (HDL) levels. This is because HDL cholesterol is often referred to as ‘good’ cholesterol. Higher levels of HDL cholesterol are associated with a lower risk of ischaemic heart disease, not an increased risk.
Smoking, diabetes mellitus, hypertension, and hypothyroidism are all recognized risk factors for ischaemic heart disease. They contribute to the development of atherosclerosis, which can lead to ischaemic heart disease.
Overview of Ischaemic Heart Disease:
Ischaemic heart disease, also known as coronary artery disease, is a condition that affects the supply of blood to the heart. It occurs when the coronary arteries become narrowed by a gradual build-up of fatty material within their walls.
The condition is the most common cause of death in the UK and worldwide.
Risk Factors for Ischaemic Heart Disease:
Smoking: Smoking damages the lining of the arteries, leading to a build-up of fatty material (atheroma).
Diabetes mellitus: High blood sugar levels can damage the arteries and lead to atherosclerosis.
Hypertension: High blood pressure can strain the heart and blood vessels, leading to ischaemic heart disease.
Hypothyroidism: Low levels of thyroid hormone can lead to high levels of bad cholesterol and increase the risk of atherosclerosis.
Prevention of Ischaemic Heart Disease:
Prevention strategies include lifestyle changes such as quitting smoking, eating a healthy diet, exercising regularly, and maintaining a healthy weight.
Medications to control blood pressure, diabetes, and cholesterol levels can also reduce the risk.
28137
Which of the following is not a preventable risk factor for coronary artery disease?
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20.51% of users got this question correct
Moderate alcohol consumption can reduce coronary artery disease risk but heavy drinking increases it.
All the other options increase the risk of ischaemic heart disease and are modifiable.