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Ischaemic Heart Disease (IHD)

Background Knowledge 🧠

Definition

  • A condition characterised by reduced blood supply to the heart muscle, usually due to coronary artery disease (CAD).

Epidemiology

  • IHD is a leading cause of death worldwide, however, due to population-wide primary prevention initiatives, the number of deaths globally have been declining.

Pathophysiology

  • Narrowing or blockage of coronary arteriesΒ reduces oxygen supplyΒ to the myocardium.

  • Prolonged ischaemia can lead to myocardial infarction.

Aetiology/Risk Factors

  • Most commonly caused by atherosclerosis of the coronary arteries.

  • Risk factors:
    • Hypertension
    • Hyperlipidaemia
    • Smoking
    • Diabetes
    • Family history
    • Age
    • Gender
    • Obesity

Clinical Features πŸŒ‘️

Symptoms

  • Angina pectoris: Chest pain or discomfort, often radiating to the left arm, neck, or jaw. Symptoms are triggered by exertion or stress.
  • Myocardial infarction: Severe, prolonged chest pain; associated with nausea, sweating, and shortness of breath.
  • Silent ischaemia: Asymptomatic episodes of myocardial ischaemia.
    • Patients with diabetes mellitus are more susceptible to silent episodes.

Investigations πŸ§ͺ

Initial Tests

  • Electrocardiogram (ECG): Detects ST-segment changes, T-wave inversions, and Q waves suggestive of ischaemia or infarction.

  • Blood tests: Cardiac enzymes (troponin, CK-MB) rise after myocardial infarction.

Diagnostic Tests

  • Coronary angiography: Gold standard for visualising coronary artery blockages.

  • Stress testing and myocardial perfusion imaging to evaluate the functional significance of coronary lesions.

Management πŸ₯Ό

Management

  • Pharmacological: Antiplatelets (aspirin, clopidogrel), statins, beta-blockers, ACE inhibitors, and nitrates.
  • Revascularisation: Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for significant obstruction or uncontrolled symptoms.
  • Lifestyle modifications: Smoking cessation, diet, exercise, and weight management.

Prognosis

  • Early detection and treatmentΒ improve outcomes.

Complications

  • Heart failure
  • Arrhythmias
  • Sudden cardiac death
  • Recurrent myocardial infarction

Key Points

  • IHD is characterised by an imbalance between blood oxygen supplyΒ and metabolic demand of the myocardium.
  • Coronary angiography is the gold standard diagnostic test.
  • Management includes both pharmacological and revascularisation interventions in addition to lifestyle modifications.

References

Office for National Statistics (2021). Ischaemic heart diseases deaths including comorbidities, England and Wales – Office for National Statistics. [online] www.ons.gov.uk. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/ischaemicheartdiseasesdeathsincludingcomorbiditiesenglandandwales/2019registrations.

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Which of the following is not a recognized risk factor for ischaemic heart disease?

They are strongly correlated.

Diabetes mellitus is another important risk factor.

Low HDL levels are correlated with increased risk.

Hypertension is a major risk factor.

This is a recognized risk factor.


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